Testing circuit-level theories of consciousness in humans

Show simple item record
dc.contributor.authorDykstra, Andrew R.
dc.contributor.authorZhu, Yunkai
dc.contributor.authorFernandez Pujol, Carolina
dc.contributor.authorZhou, David W.
dc.contributor.authorJones, Stephanie R.
dc.contributor.authorMarvan, Tomáš
dc.contributor.authorBonaiuto, James J.
dc.date.accessioned2025-10-01T06:57:28Z
dc.date.available2025-10-01T06:57:28Z
dc.date.issued2025
dc.description.abstract-translatedOur understanding of the neural basis of consciousness is mostly restricted to large-scale brain activity patterns as measured by methods such as functional magnetic resonance imaging (fMRI) and magneto/electro-encephalography (M/EEG). In contrast, we lack even basic understanding of circuit-level mechanisms supporting consciousness – particularly in humans – despite the fundamental role that such mechanisms likely play in instantiating larger-scale brain activity patterns supporting conscious states and contents. Here, we review what progress has been made on circuit-level theories of consciousness (e.g., apical amplification theory, dendritic integration theory) and argue that such theories can be tested in humans using recently developed, state-of-the-art methods. Doing so will further facilitate translation of consciousness science into clinical settings and strengthen the bridge between circuit- and network-level theories of consciousness.en
dc.description.sponsorshipThis work was supported by Fondation pour l’Audition grant RD-2022-03 to J.B. and A.D., National Institutes of Deafness and Communication Sciences (NIDCD) grant R21DC020295 to A.D., National Institute of Neurological Disorders and Stroke (NINDS) grant U24NS129945 to S.J., the University of Central Florida, Programme Johannes Amos Comenius (P JAC-MSMT) grant reg. n. CZ.02.01.01/00/23_025/0008715 to T.M., and European Research Council (ERC) consolidator grant 864550 to J.B.en
dc.format13 s.cs
dc.identifier.doihttps://doi.org/10.1016/j.tics.2025.08.012
dc.identifier.urihttp://hdl.handle.net/11025/62870
dc.language.isoenen
dc.publisherElsevieren
dc.rights© 2025 The Authorsen
dc.rights.accessopenAccessen
dc.subjectvědomícs
dc.subjectteorie apikální amplifikacecs
dc.subjectteorie dendritické integracecs
dc.subjectneurozobrazovánícs
dc.subjectpyramidální neuronycs
dc.subjectbiofyzikální modelovánícs
dc.subject.translatedconsciousnessen
dc.subject.translatedapical amplification theoryen
dc.subject.translateddendritic integration theoryen
dc.subject.translatedneuroimagingen
dc.subject.translatedpyramidal neuronsen
dc.subject.translatedbiophysical modelingen
dc.titleTesting circuit-level theories of consciousness in humansen
dc.typearticleen
dc.typečlánekcs
dc.type.statusPeer revieweden
dc.type.versionpublishedVersionen
local.files.count1*
local.files.size1006470*
local.has.filesyes*

Files

Original bundle
Showing 1 - 1 out of 1 results
No Thumbnail Available
Name:
1-s2.0-S1364661325002372-main.pdf
Size:
982.88 KB
Format:
Adobe Portable Document Format
Download
License bundle
Showing 1 - 1 out of 1 results
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

OBD
 Articles (KFI)