Profilace u myší s obezitou indukovanou na základě diety a s diabetem 2. typu po léčbě s metforminem a vildagliptinu a jejich kombinací na základě metabolomické analýzy moči

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dc.contributor.authorPelantová, Helena
dc.contributor.authorBugáňová, Martina
dc.contributor.authorHolubová, Martina
dc.contributor.authorŠedivá, Blanka
dc.contributor.authorZemenová, Jana
dc.contributor.authorSýkora, David
dc.contributor.authorKaválková, Petra
dc.contributor.authorHaluzík, Martin
dc.contributor.authorŽelezná, Blanka
dc.contributor.authorMaletínská, Lenka
dc.contributor.authorKuneš, Jaroslav
dc.contributor.authorKuzma, Marek
dc.date.accessioned2017-03-02T09:52:21Z
dc.date.available2017-03-02T09:52:21Z
dc.date.issued2016
dc.description.abstract-translatedMetformin, vildagliptin and their combination are widely used for the treatment of diabetes, but little is known about the metabolic responses to these treatments. In the present study, NMR-based metabolomics was applied to detect changes in the urinary metabolomic profile of a mouse model of diet-induced obesity in response to these treatments. Additionally, standard biochemical parameters and the expression of enzymes involved in glucose and fat metabolism were monitored. Significant correlations were observed between several metabolites (e.g., N-carbamoyl-β-alanine, N1-methyl-4-pyridone-3-carboxamide, N1-methyl-2-pyridone-5-carboxamide, glucose, 3-indoxyl sulfate, dimethylglycine and several acylglycines) and the area under the curve of glucose concentrations during the oral glucose tolerance test. The present study is the first to present N-carbamoyl-β-alanine as a potential marker of type 2 diabetes mellitus and consequently to demonstrate the efficacies of the applied antidiabetic interventions. Moreover, the elevated acetate level observed after vildagliptin administration might reflect increased fatty acid oxidation.en
dc.format13 s.cs
dc.format.mimetypeapplication/pdf
dc.identifier.citationZAJÍC, Zbyněk. Smoothing factor in discriminative feature adaptation. In: Studentská Vědecká Konference 2010. [S. n.]: Studentská Vědecká Konference, 2010, s. 57-58.en
dc.identifier.doi10.1016/j.mce.2016.05.003
dc.identifier.issn0303-7207
dc.identifier.obd43917641
dc.identifier.urihttp://hdl.handle.net/11025/25702
dc.identifier.urihttps://www.scopus.com/record/display.uri?origin=resultslist&eid=2-s2.0-84971222599
dc.language.isoenen
dc.publisherElsevieren
dc.rightsPlný text není přístupný.cs
dc.rights© Elsevieren
dc.rights.accessclosedAccessen
dc.subjectNMR metabolomikacs
dc.subjectmyšics
dc.subjectobezitacs
dc.subjectdiabetes mellitus 2. typucs
dc.subjectmočcs
dc.subjectléčba diabetucs
dc.subject.translatedNMR metabolomicsen
dc.subject.translatedmouseen
dc.subject.translatedobesityen
dc.subject.translatedtype 2 diabetes mellitusen
dc.subject.translatedurineen
dc.subject.translatedantidiabetic treatmenten
dc.titleProfilace u myší s obezitou indukovanou na základě diety a s diabetem 2. typu po léčbě s metforminem a vildagliptinu a jejich kombinací na základě metabolomické analýzy močics
dc.titleUrinary metabolomic profiling in mice with diet-induced obesity and type 2 diabetes mellitus after treatment with metformin and vildagliptin and their combinationen
dc.typečlánekcs
dc.typearticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen

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