TdP Incidence in Methoxamine-Sensitized Rabbit Model Is Reduced With Age but Not Influenced by Hypercholesterolemia

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dc.contributor.authorAromolaran, Ademuyiwa S.
dc.contributor.authorNalos, Lukáš
dc.contributor.authorJarkovská, Dagmar
dc.contributor.authorŠvíglerová, Jitka
dc.contributor.authorSüß, Annabell
dc.contributor.authorZáleský, Jakub
dc.contributor.authorRajdl, Daniel
dc.contributor.authorKrejčová, Milada
dc.contributor.authorKuncová, Jitka
dc.contributor.authorRosenberg, Josef
dc.contributor.authorŠtengl, Milan
dc.date.accessioned2021-08-30T10:00:16Z
dc.date.available2021-08-30T10:00:16Z
dc.date.issued2021
dc.description.abstract-translatedMetabolic syndrome is associated with hypercholesterolemia, cardiac remodeling, and increased susceptibility to ventricular arrhythmias. Effects of diet-induced hypercholesterolemia on susceptibility to torsades de pointes arrhythmias (TdP) together with potential indicators of arrhythmic risk were investigated in three experimental groups of Carlsson’s rabbit model: (1) young rabbits (YC, young control, age 12–16 weeks), older rabbits (AC, adult control, age 20–24 weeks), and older age-matched cholesterol-fed rabbits (CH, cholesterol, age 20–24 weeks). TdP was induced by α-adrenergic stimulation by methoxamine and IKr block in 83% of YC rabbits, 18% of AC rabbits, and 21% of CH rabbits. High incidence of TdP was associated with high incidence of single (SEB) and multiple ectopic beats (MEB), but the QTc prolongation and short-term variability (STV) were similar in all three groups. In TdP-susceptible rabbits, STV was significantly higher compared with arrhythmia-free rabbits but not with rabbits with other than TdP arrhythmias (SEB, MEB). Amplitude-aware permutation entropy analysis of baseline ECG could identify arrhythmia-resistant animals with high sensitivity and specificity. The data indicate that the TdP susceptibility in methoxamine-sensitized rabbits is affected by the age of rabbits but probably not by hypercholesterolemia. Entropy analysis could potentially stratify the arrhythmic risk and identify the low-risk individuals.en
dc.format11 s.cs
dc.format.mimetypeapplication/pdf
dc.identifier.citationNALOS, L., JARKOVSKÁ, D., ŠVÍGLEROVÁ, J., SÜß, A., ZÁLESKÝ, J., RAJDL, D., KREJČOVÁ, M., KUNCOVÁ, J., ROSENBERG, J., ŠTENGL, M., AROMOLARAN, AS. TdP Incidence in Methoxamine-Sensitized Rabbit Model Is Reduced With Age but Not Influenced by Hypercholesterolemia. Frontiers in Physiology, 2021, roč. 12, č. červen, s. 1-11. ISSN 1664-042X.cs
dc.identifier.document-number669462400001
dc.identifier.doi10.3389/fphys.2021.692921
dc.identifier.issn1664-042X
dc.identifier.obd43933112
dc.identifier.uri2-s2.0-85109135134
dc.identifier.urihttp://hdl.handle.net/11025/44962
dc.language.isoenen
dc.project.IDEF17_048/0007280/Aplikace moderních technologií v medicíně a průmyslucs
dc.publisherFrontiers Mediaen
dc.relation.ispartofseriesFrontiers in Physiologyen
dc.rights© Frontiers Mediaen
dc.rights.accessopenAccessen
dc.subject.translatedhypercholesterolemia, TdP arrhythmia, arrhythmia risk prediction, rabbit, amplitude-aware permutation entropyen
dc.titleTdP Incidence in Methoxamine-Sensitized Rabbit Model Is Reduced With Age but Not Influenced by Hypercholesterolemiaen
dc.typečlánekcs
dc.typearticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen

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