Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications

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dc.contributor.authorYin, Bohan
dc.contributor.authorGosecka, Monika
dc.contributor.authorBodaghi, Mahdi
dc.contributor.authorCrespy, Daniel
dc.contributor.authorYoussef, George
dc.contributor.authorDodda, Jagan Mohan
dc.contributor.authorWong, Siu Hong Dexter
dc.contributor.authorImran, Abu Bin
dc.contributor.authorGosecki, Mateusz
dc.contributor.authorJobdeedamrong, Arjaree
dc.contributor.authorAfzali Naniz, Moqaddaseh
dc.contributor.authorZolfagharian, Ali
dc.date.accessioned2024-12-18T13:04:17Z
dc.date.available2024-12-18T13:04:17Z
dc.date.issued2024
dc.description.abstract-translatedHydrogels have emerged in various biomedical applications, including tissue engineering and medical devices, due to their ability to imitate the natural extracellular matrix (ECM) of tissues. However, conventional static hydrogels lack the ability to dynamically respond to changes in their surroundings to withstand the robust changes of the biophysical microenvironment and to trigger on-demand functionality such as drug release and mechanical change. In contrast, multifunctional dynamic hydrogels can adapt and respond to external stimuli and have drawn great attention in recent studies. It is realized that the integration of nanomaterials into dynamic hydrogels provides numerous functionalities for a great variety of biomedical applications that cannot be achieved by conventional hydrogels. This review article provides a comprehensive overview of recent advances in designing and fabricating dynamic hydrogels for biomedical applications. We describe different types of dynamic hydrogels based on breakable and reversible covalent bonds as well as noncovalent interactions. These mechanisms are described in detail as a useful reference for designing crosslinking strategies that strongly influence the mechanical properties of the hydrogels. We also discuss the use of dynamic hydrogels and their potential benefits. This review further explores different biomedical applications of dynamic nanocomposite hydrogels, including their use in drug delivery, tissue engineering, bioadhesives, wound healing, cancer treatment, and mechanistic study, as well as multiple-scale biomedical applications. Finally, we discuss the challenges and future perspectives of dynamic hydrogels in the field of biomedical engineering, including the integration of diverse technologies.en
dc.description.sponsorshipEH22_008/0004634 Strojní inženýrství biologických a bioinspirovaných systémůcs
dc.format38 s.cs
dc.identifier.doihttps://doi.org/10.1016/j.cej.2024.150403
dc.identifier.issn1385-8947
dc.identifier.urihttp://hdl.handle.net/11025/57980
dc.language.isoenen
dc.publisherElsevieren
dc.rights© CC BY 4.0en
dc.rights.accessopenAccessen
dc.subjectdynamický hydrogelcs
dc.subjectbioadhezivnícs
dc.subjectnanokompozitcs
dc.subjectbiomedicínské aplikacecs
dc.subject.translateddynamic hydrogelen
dc.subject.translatedbioadhesiveen
dc.subject.translatednanocompositeen
dc.subject.translatedbiomedical applicationsen
dc.titleEngineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applicationsen
dc.typearticleen
dc.typečlánekcs
dc.type.statusPeer revieweden
dc.type.versionpublishedVersionen
local.files.count1*
local.files.size24609906*
local.has.filesyes*

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