Common, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0

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dc.contributor.authorHurley, Carolyn K.
dc.contributor.authorKempenich, Jane
dc.contributor.authorWadsworth, Kim
dc.contributor.authorSauter, Jürgen
dc.contributor.authorHofmann, Jan A.
dc.contributor.authorSchefzyk, Daniel
dc.contributor.authorSchmidt, Alexander A.
dc.contributor.authorGalarza, Pablo
dc.contributor.authorCardozo, Maria B.R.
dc.contributor.authorDudkiewicz, Malgorzata
dc.contributor.authorHoudová, Lucie
dc.contributor.authorJindra, Pavel
dc.contributor.authorSorensen, Betina S.
dc.contributor.authorJagannathan, Latha
dc.contributor.authorMathur, Ankit
dc.contributor.authorLinjama, Tiina
dc.contributor.authorTorosian, Tigran
dc.contributor.authorFreudenberger, Rafi
dc.contributor.authorManolis, Anastasios
dc.contributor.authorMavrommatis, John
dc.contributor.authorCereb, Nezih
dc.contributor.authorManor, Sigal
dc.contributor.authorShriki, Nira
dc.contributor.authorSacchi, Nicoletta
dc.contributor.authorAmeen, Reem
dc.contributor.authorFisher, Raewyn
dc.contributor.authorDunckley, Heather
dc.contributor.authorAndersen, Irene
dc.contributor.authorAlaskar, Ahmed
dc.contributor.authorAlzahrani, Mohsen
dc.contributor.authorHajeer, Ali
dc.contributor.authorJawdat, Dunia
dc.contributor.authorNicoloso, Grazia
dc.contributor.authorKupatawintu, Pawinee
dc.contributor.authorCho, Louise
dc.contributor.authorKaur, Ashminder
dc.contributor.authorBengtsson, Mats
dc.contributor.authorDehn, Jason
dc.date.accessioned2021-02-08T11:00:23Z
dc.date.available2021-02-08T11:00:23Z
dc.date.issued2020
dc.description.abstract-translatedA catalog of common, intermediate and well-documented (CIWD) HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, -DQB1 and -DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two-field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well-documented (≥5 occurrences) or not-CIWD. Overall 26% of alleles in IPD-IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two-field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well-documented alleles. Full-field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole.en
dc.format16 s.cs
dc.format.mimetypeapplication/pdf
dc.identifier.citationHURLEY, C. K., KEMPENICH, J., WADSWORTH, K., SAUTER, J., HOFMANN, J. A., SCHEFZYK, D., SCHMIDT, A. A., GALARZA, P., CARDOZO, M. B., DUDKIEWICZ, M., HOUDOVÁ, L., JINDRA, P., SORENSEN, B. S., JAGANNATHAN, L., MATHUR, A., LINJAMA, T., TOROSIAN, T., FREUDENBERGER, R., MANOLIS, A., MAVROMMATIS, J., CEREB, N., MANOR, S., SHRIKI, N., SACCHI, N., AMEEN, R., FISHER, R., DUNCKLEY, H., ANDERSEN, I., ALASKAR, A., ALZAHRANI, M., HAJEER, A., JAWDAT, D., NICOLOSO, G., KUPATAWINTU, P., CHO, L., KAUR, A., BENGTSSON, M., DEHN, J. Common, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0. Hla, 2020, roč. 95, č. 6, s. 516-531. ISSN 2059-2302.cs
dc.identifier.document-number510264700001
dc.identifier.doi10.1111/tan.13811
dc.identifier.issn2059-2302
dc.identifier.obd43927419
dc.identifier.uri2-s2.0-85078839466
dc.identifier.urihttp://hdl.handle.net/11025/42601
dc.language.isoenen
dc.project.IDLO1506/PUNTIS - Podpora udržitelnosti centra NTIS - Nové technologie pro informační společnostcs
dc.publisherBlackwell Publishingen
dc.relation.ispartofseriesHlaen
dc.rights© Blackwell Publishingen
dc.rights.accessopenAccessen
dc.subject.translatedCIWD catalogueen
dc.subject.translatedHLAen
dc.subject.translatedallelesen
dc.subject.translatedpopulation geneticsen
dc.subject.translatedethnic groups, gene frequencyen
dc.titleCommon, Intermediate and Well-Documented HLA Alleles in World Populations: CIWD Version 3.0.0en
dc.typečlánekcs
dc.typearticleen
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen

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