Titanium-based porous materials with nanostructured bioactive surface for enhanced osseointegration

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dc.contributor.authorKřenek, Tomáš
dc.contributor.authorKovařík, Tomáš
dc.contributor.authorDocheva, Denitsa
dc.contributor.authorStich, Theresia
dc.contributor.authorKadlec, Jaroslav
dc.contributor.editorKučerová, Ludmila
dc.contributor.editorJirková, Hana
dc.contributor.editorJeníček, Štěpán
dc.date.accessioned2019-10-08T13:32:29Z
dc.date.available2019-10-08T13:32:29Z
dc.date.issued2019
dc.description.abstract-translatedDespite the great progress that has been achieved in orthopedics biomaterials, fixation of implants to the bone host remains a problem. Mismatch of Young’s moduli of the biomaterials and the surrounding bone has been identified as a major reason for implant loosening following stress shielding of bone. However, the implanted material must be strong enough and durable to withstand the physiological loads placed upon it over the years. A suitable balance between strength and stiffness has to be found to the best match of bone behaviour. Titanium and its alloy (Ti6Al4V) have elastic moduli less than 50% of that commonly used Co–Cr implants so that their use helps reduce the extent of stress shielding. One consideration to achieve this has been the development of materials that exhibit substantial surface or total bulk porosity in medical applications. Moreover, bioactive surface chemical composition and suitable surface morphology on micro- and nanoscale level is necessary for efficient osseointegration. Here we report on novel concept of hierarchically functionalized titanium based biomaterials consists in (i) laser induced surface porosity, (ii) micro/messoporous bioactive glass fillers, (iii) chemical activation and/or ablative deposition of bioactive CaTiO3 nanoparticles. Prepared biomaterials were analyzed using SEM/EDX, XRD, Raman spectroscopy and test in terms of cell cultivation in order to reveal biocompatibility, cell viability and osseointegration ability.en
dc.description.sponsorshipPING 2019 is organized with the support of funds for specific university research project SVK1-2019-002.en
dc.format1 s.cs
dc.format.mimetypeapplication/PDF
dc.identifier.citationJIRKOVÁ, Hana ed.; JENÍČEK, Štepán ed. Proceedings PING 2019: modern trends in material engineering: 10.-13.09.2019, Pilsen. 1. vyd. Plzeň: University of West Bohemia, 2019, s. 110. ISBN 978-80-261-0879-5.en
dc.identifier.isbn978-80-261-0879-5
dc.identifier.urihttp://hdl.handle.net/11025/35271
dc.language.isoenen
dc.publisherUniversity of West Bohemiaen
dc.rights© University of West Bohemiaen
dc.rights.accessopenAccessen
dc.subjectbiomateriálycs
dc.subjecttitancs
dc.subjectpórovitostcs
dc.subjectnanostrukturovaný povrchcs
dc.subjectchemická aktivacecs
dc.subjectživotaschopnost buněkcs
dc.subject.translatedbiomaterialsen
dc.subject.translatedtitaniumen
dc.subject.translatedporosityen
dc.subject.translatednanostructured surfaceen
dc.subject.translatedchemical activationen
dc.subject.translatedcell viabilityen
dc.titleTitanium-based porous materials with nanostructured bioactive surface for enhanced osseointegrationen
dc.typekonferenční příspěvekcs
dc.typeconferenceObjecten
dc.type.statusPeer-revieweden
dc.type.versionpublishedVersionen

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