A comparative study of 1D and 3D hemodynamics in patient-specific hepatic portal vein networks
Date issued
2014
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of West Bohemia
Abstract
The development of software for use in clinical practice is often associated with many requirements and restrictions
set not only by the medical doctors, but also by the hospital’s budget. To meet the requirement of reliable software,
which is able to provide results within a short time period and with minimal computational demand, a certain
measure of modelling simplification is usually inevitable. In case of blood flow simulations carried out in large
vascular networks such as the one created by the hepatic portal vein, simplifications are made by necessity.
The most often employed simplification includes the approach in the form of dimensional reduction, when the
3D model of a large vascular network is substituted with its 1D counterpart. In this context, a question naturally
arises, how this reduction can affect the simulation accuracy and its outcome. In this paper, we try to answer this
question by performing a quantitative comparison of 3D and 1D flow models in two patient-specific hepatic portal
vein networks. The numerical simulations are carried out under average flow conditions and with the application
of the three-element Windkessel model, which is able to approximate the downstream flow resistance of real
hepatic tissue. The obtained results show that, although the 1D model can never truly substitute the 3D model, its
easy implementation, time-saving model preparation and almost no demands on computer technology dominate as
advantages over obvious but moderate modelling errors arising from the performed dimensional reduction.
Description
Subject(s)
průtok krve, průtokový model, metoda konečných objemů, Windkesselův model, hemodynamika, 1D modely, 3D modely, počítačová simulace, portální žíla
Citation
Applied and Computational Mechanics. 2014, vol. 8, no. 2, p. 177-186.